C. Brad Shuster

Biography

My laboratory studies how cell division and the cytoskeleton are regulated within the context of early development. Cell division is a process fundamental to all organisms, and coordinate regulation of the actin and microtubules is essential for cells to correctly segregate the replicated sister chromatids and partition the two daughter cells. This has been intensely studied in a variety of systems, but significant questions remain regarding how changes in cell shape are regulated in space and time. In an effort to answer these questions, we employ molecular, biochemical and imaging approaches to study these processes in model systems ranging from yeast and the eggs of marine invertebrates to cultured human cells. From these lines of experimentation, we hope to understand how the final events of cell division are regulated in space and time during development and disease.